| Advances in the Immunology of the Host–Parasite Interactions in African Trypanosomosis, including Single-Cell Transcriptomics |
|
| Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids |
|
| Recent Progress in the Detection of Surra, a Neglected Disease Caused by Trypanosoma evansi with a One Health Impact in Large Parts of the Tropic and Sub-Tropic World |
|
| Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N-terminal domain |
|
| Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis |
|
| Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge |
|
| Nanobodies: A Review of Generation, Diagnostics and Therapeutics |
|
| Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021: Towards refinement of COVID-19 disease vaccines, diagnostics, and therapeutics |
|
| Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome infections |
|
| Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030 |
|
| The Pathogenesis of African Trypanosomiasis |
|
| The COMBAT project: controlling and progressively minimizing the burden of vector-borne animal trypanosomosis in Africa |
|
| The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm |
|
| Trypanosoma brucei brucei Infection Depletes Memory B Cells Resulting in Inability of the Host to Recall Protective B Cells Responses |
|
| Improving the yield of recalcitrant Nanobodies® by simple modifications to the standard protocol |
|
| African trypanosomosis obliterates dtpa vaccine-induced functional memory so that post-treatment bordetella pertussis challenge fails to trigger a protective recall response |
|
| Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis |
|
| BCG-mediated protection against M. tuberculosis is sustained post-malaria infection independent of parasite virulence |
|
| The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates |
|
| Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System |
|
| Comprehensive genomic analysis reveals virulence factors and antibiotic resistance genes in Pantoea agglomerans KM1, a potential opportunistic pathogen |
|
| A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection |
|
| Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System |
|
| An Unbiased Immunization Strategy Results in the Identification of Enolase as a Potential Marker for Nanobody-Based Detection of Trypanosoma evansi |
|
| T. brucei infections abrogate diverse plasma cell-mediated effector B cell responses, independently of their specificity, affinity and host genetic background. |
|
| Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase |
|
| Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections |
|
| Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection. |
|
| The trypanosomal transferrin receptor of Trypanosoma brucei—a review |
|
| Using detergent-enhanced LAMP for African trypanosome detection in human cerebrospinal fluid and implications for disease staging |
|
| Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice |
|
| Effects of Different Land Uses (Abandoned Farmland, Intensive Agriculture and Forest) on Soil Hydrological Properties in Southern Spain |
|
| Development of camelid nanobody based-LAM Pole diagnostic tests for dengue and Zika viruses |
|
| Salivarian trypanosomosis: A review of parasites involved, their global distribution and their interaction with the innate and adaptive mammalian host immune system |
|
| Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis |
|
| Neutrophils enhance early Trypanosoma brucei infection onset |
|
| Development of a Nanobody-based lateral flow assay to detect active Trypanosoma congolense infections |
|
| Correction |
|
| Corrigendum to "DNA detection of Trypanosoma evansi |
|
| African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System |
|
| DNA detection of Trypanosoma evansi: Diagnostic validity of a new assay based on loop-mediated isothermal amplification (LAMP) |
|
| Structural basis for the high specificity of a Trypanosoma congolense immunoassay targeting glycosomal aldolase |
|
| Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis. |
|
| Functionalization of gold nanoparticles with nanobodies through physical adsorption |
|
| The non-mammalian MIF superfamily (Reprinted from Immunobiology, vol 222, pg 473-482, 2017) |
|
| African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses? |
|
| Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells |
|
| The non-mammalian MIF superfamily |
|
| Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. |
|
| The Enrichment of Histomonas meleagridis and Its Pathogen-Specific Protein Analysis |
|
| MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis |
|
| Infection of mice by Trypanosoma brucei ameliorates host immune response against Brucella melitensis |
|
| Comparative evaluation of the nested ITS PCR against the 18S PCR-RFLP in a survey of bovine trypanosomiasis in Kwale County, Kenya |
|
| Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells |
|
| Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity |
|
| In vivo characterization of two additional Leishmania donovani strains using the murine and hamster model. |
|
| An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase |
|
| Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis |
|
| Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development |
|
| Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis |
|
| IFN-γ mediates early B-cell loss in experimental African trypanosomosis |
|
| Curative drug treatment of trypanosomosis leads to the restoration of B-cell lymphopoiesis and splenic B-cell compartments |
|
| IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ |
|
| Experimental African Trypanosome Infection by Needle Passage or Natural Tsetse Fly Challenge Thwarts the Development of Collagen-Induced Arthritis in DBA/1 Prone Mice via an Impairment of Antigen Specific B Cell Autoantibody Titers |
|
| NK-, NKT- and CD8-Derived IFN gamma Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia |
|
| Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax |
|
| Detection of Pathogen-Specific Antibodies by Loop-Mediated Isothermal Amplification |
|
| Escape mechanisms of African trypanosomes |
|
| Development of a pHrodo-Based Assay for the Assessment of In Vitro and In Vivo Erythrophagocytosis during Experimental Trypanosomosis |
|
| Monovinyl sulfone B-cyclodextrin. a flexible drug carrier system |
|
| Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes |
|
| Coadministration of protoxin Cry1Ac from Bacillus thuringiensis with metacestode extract confers protective immunity to murine cysticercosis |
|
| Antibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor |
|
| Chronic Trypanosoma congolense infections in mice cause a sustained disruption of the B- cell homeostasis in the bone marrow and spleen |
|
| Nitric oxide production by endotoxin preparations in TLR4-deficient mice |
|
| Utilizing Nanobody Technology to Target Non-Immunodominant Domains of VAR2CSA |
|
| Novel therapy based on camelid nanobodies |
|
| Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies |
|
| Tsetse Salivary Gland Proteins 1 and 2 Are High Affinity Nucleic Acid Binding Proteins with Residual Nuclease Activity |
|
| Enrichment of Histomonas meleagridis |
|
| Unravelling the events leading to inflammation-induced trypanosomiasis-associated acute anemia |
|
| Two unique IL-10 producing B cell subsets contribute to the host cytokine balance during Trypanosoma brucei infections |
|
| Adenylate Cyclases of Trypanosoma brucei Inhibit the Innate Immune Response of the Host |
|
| Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier |
|
| In Situ Microscopy Analysis Reveals Local Innate Immune Response Developed around Brucella Infected Cells in Resistant and Susceptible Mice |
|
| Analysis of blood-brain barrier permeability of monovalent nanobodies using microdialysis |
|
| Insufficiently Defined Genetic Background Confounds Phenotypes in Transgenic Studies As Exemplified by Malaria Infection in Tlr9 Knockout Mice |
|
| Vaccination against trypanosomiasis Can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist? |
|
| TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation |
|
| Mouse models for pathogenic African trypanosomes: unravelling the immunology of host-parasite-vector interactions |
|
| High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis |
|
| T-brucei Infection Reduces B Lymphopoiesis in Bone Marrow and Truncates Compensatory Splenic Lymphopoiesis through Transitional B-Cell Apoptosis |
|
| Acute disruption of bone marrow B lymphopoiesis and apoptosis of transitional and marginal zone B cells in the spleen following a blood-stage Plasmodium chabaudi infection in mice. |
|
| Parasite-induced B-cell apoptosis results in loss of specific protective anti-trypanosome antibody responses, and abolishment of vaccine induced protective memory responses. |
|
| African trypanosomiasis |
|
| Current status of vaccination against African trypanosomiasis |
|
| Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis |
|
| The Central role of Macrophages in Trypanosomiasis-Associated Anemia: Rationale for Therapeutical Approaches. |
|
| Receptor-Mediated and Lectin-Like Activities of Carp (Cyprinus carpio) TNF-alpha |
|
| African trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosis |
|
| iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice |
|
| Camelid immunoglobulins and nanobody technology |
|
| Camel antibodies for therapeutic and research applications |
|
| THE ROLE OF TNF AND MYD88 IN THE INDUCTION OF B CEL PATHOLOGY FOLLOWING TRYPANOSOMA BRUCEI INFECTION |
|
| Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection |
|
| Contributions of experimental mouse models to the understanding of African trypanosomiasis |
|
| Stimulation of Toll-like receptor 3 and 4 induces interleukin-1 beta maturation by caspase-8 |
|
| The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice |
|
| Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses |
|
| Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens |
|
| Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated trypanosoma congolense parasite killing |
|
| Interleukin-12p70-dependent interferon-gamma production is crucial for resistance in African trypanosomiasis |
|
| African trypanosomosis: From immune escape and in-immunopathology to immune intervention |
|
| A glycosylphosphatidylinositol-based treatment alleviates trypanosomiasis-associated immunopathology |
|
| Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response |
|
| Deletion of IL-4R alpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection |
|
| Traitement expérimental de la trypanosomiase Africaine par le facteur trypanolytique humain combiné à un nanocorps |
|
| Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response |
|
| Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor |
|
| Identification of a trypatophan-like epitope borne by the variable surface glycoprotein (VSG) of African trypanosomes |
|
| Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment |
|
| Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 infections. |
|
| The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent |
|
| P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis |
|
| Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies - African trypanosomes as paradigm |
|
| The functional relevance of the lectin-like activities of cytokines: TNF as an illustrative example |
|
| The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense |
|
| Direct detection and identification of African trypanosomes by fluorescence in situ hybridization with peptide nucleic acid probes |
|
| Selective pressure can influence the resistance of Trypanosoma congolense to normal human serum. |
|
| Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense |
|
| VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology |
|
| Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-alpha induction |
|
| A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding molecule. |
|
| Comparative analysis of antibody responses against HSP60, ISG70 and VSG reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei |
|
| Antibodies raised against the flagellar pocket fraction of Trypanosoma brucei preferentially recognize HSP60 in cDNA expression library |
|
| Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages |
|
| Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei |
|
| Hemozoin is a key factor in the induction of malaria-associated immunosuppression |
|
| Convergent evolution of cytokines |
|
| Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections |
|
| TNF-alpha plays a key role in the regulation of the experimental infection with Trypanosoma brucei |
|
| The glycosyl-inositol-phosphate and dimyristoglycerol moieties of the GPI-anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophages activating factors |
|
| Trypanosoma brucei infections elicit nitric oxide-dependent and nitric oxide-independent suppressive mechanism |
|
| The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors |
|
| Cell signalling in trypanosomatids. |
|
| Generation of a mouse tumor necrosis factor mutant with antiperitonitis and desensitization activities comparable to those of the wild type but with reduced systemic toxicity |
|
| Specific uptake of tumor necrosis factor-alpha is involved in growth control of Trypanosoma brucei |
|
| MAPPING THE LECTIN-LIKE ACTIVITY OF TUMOR-NECROSIS-FACTOR |
|
| Murine tumor necrosis factor plays a protective role during the initial phase of parasitaemia in trypanosusceptible mice infected experimentally with Trypanosoma brucei brucei |
|
| Mechanisms underlying Trypanosome-elicted immunosupression |
|
