| Synthesis of polysubstituted azepanes by dearomative ring expansion of nitroarenes |
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| Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1 |
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| Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists |
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| Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor |
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| Relating Conformational Equilibria to Conformer-Specific Lipophilicities: New Opportunities in Drug Discovery |
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| Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor |
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| Impact of PROTAC Linker Plasticity on the Solution Conformations and Dissociation of the Ternary Complex |
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| Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C |
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| Diversity-orientated synthesis of macrocyclic heterocycles using a double SNAr approach |
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| Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides |
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| Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C |
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| Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments |
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| Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist |
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| Tricyclic Indazoles - A Novel Class of Selective Estrogen Receptor Degrader Antagonists |
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| Free Ligand 1D NMR Conformational Signatures to Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles |
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| Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry |
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| Observing an Antisense Drug Complex in Intact Human Cells by in-Cell NMR Spectroscopy |
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| Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma |
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| Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC to Provide Insight into Small Molecule Targeting of BCL6 |
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| Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors |
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| In vivo detection of perinatal brain metabolite changes in a rabbit model of intrauterine growth restriction (IUGR) |
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| Chemical shift assignments and secondary structure of the surrogate domain for drug discovery studies of human heparanase |
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| NMR structure of bitistatin - A missing piece in the evolutionary pathway of snake venom disintegrins |
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| Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action |
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| Apaf-1 inhibitors protect from unwanted cell death in In vivo models of kidney ischemia and chemotherapy induced ototoxicity |
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| New clicked thiirane derivatives as gelatinase inhibitors: The relevance of the P1? segment |
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| Synthesis of fucosyl-N-Acetylglucosamine disaccharides by transfucosylation using ?-L-Fucosidases from Lactobacillus casei |
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| Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches |
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| Metabolomic profile of umbilical cord blood plasma from early and late intrauterine growth restricted (IUGR) neonates with and without signs of brain vasodilation |
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| Progress towards water-soluble triazole-based selective MMP-2 inhibitors |
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| Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments |
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| Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin |
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| Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1 |
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| Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus |
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| NMR structure and dynamics of recombinant wild type and mutated jerdostatin, a selective inhibitor of integrin alpha(1)beta(1) |
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| Potent "clicked" MMP2 inhibitors: Synthesis, molecular modeling and biological exploration |
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| Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain |
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| Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: Tailoring modification of 3-methyl-aspartate |
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| Production of heparanase constructs suitable for nuclear magnetic resonance and drug discovery studies |
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| Polymer coiled-coil conjugates: Potential for development as a new class of therapeutic "molecular Switch" |
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| Contributions of computational chemistry and biophysical techniques to fragment-based drug discovery |
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| Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins |
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| Antimicrobial Peptides and Their Superior Fluorinated Analogues: Structure-Activity Relationships as Revealed by NMR Spectroscopy and MD Calculations |
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| The bronze age of science in Spain |
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| Polymer therapeutics containing coiled-coils: New therapeutics and linkers |
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| Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles |
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| A kernel for open source drug discovery in tropical diseases |
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| Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors |
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| A kernel for the tropical disease initiative |
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| Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives |
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| Solvent-exposed residues located in the ?-sheet modulate the stability of the tetramerization domain of p53-A structural and combinatorial approach |
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| Spain should implement a model that's known to work |
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| Polymer conjugates as therapeutics: Future trends, challenges and opportunities |
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| Polymer masked-unmasked protein therapy. 1. Bioresponsive dextrin-trypsin and -melanocyte stimulating hormone conjugates designed for ?-amylase activation |
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| How the N-terminal Domain of the OSCP Subunit of Bovine F1Fo-ATP Synthase Interacts with the N-terminal Region of an Alpha Subunit |
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| Asymmetric synthesis of fluorinated amino macrolactones through ring-closing metathesis |
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| Structure of the F-1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit |
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| Solution structure of subunit F6 from the peripheral stalk region of ATP synthase from bovine heart mitochondria |
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| Homologous and heterologous inhibitory effects of ATPase inhibitor proteins on F-ATPases |
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| Solution structure of a C-terminal coiled-coil domain from bovine IF1: The inhibitor protein of F-1 ATPase |
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| Detection of natural abundance nitrogen-15 through phosphorus-31 using pulsed field gradients |
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| Solution studies of chymotrypsin inhibitor-2 glutamine insertion mutants show no interglutamine interactions |
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| Inversion of the anomeric configuration of the transferred sugar during inactivation of the macrolide antibiotic oleandomycin catalyzed by a macrolide glycosyltransferase |
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| Glycosylation of macrolide antibiotics. Purification and kinetic studies of a macrolide glycosyltransferase from Streptomyces antibioticus |
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| Mono and dinuclear tungsten alkenyl-carbyne complexes bridged by cyanide and diisocyanide ligands: Synthesis, electrochemical- and W-183-NMR studies |
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| Pulse sequences for NMR quantum computers: How to manipulate nuclear spins while freezing the motion of coupled neighbours |
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| Synthesis and proton, nitrogen, phosphorus and tungsten multinuclear magnetic resonance study of bis(dioxybiphenyl)bis(oxypyridine)cyclotriphosphazene and dioxybiphenyl tetrakis(oxypyridine)cyclotriphosphazene and their pentacarbonyl tungsten complexes |
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| Assignment of the H-1 and C-13 NMR spectra of 9-deoxo-9a-aza-9a-homoerythromycin A, 9-deoxo-9a-aza-9a-homoerythromycin A 11,12-hydrogenborate and azithromycin 11,12-hydrogenborate |
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| W-183 NMR study of alkenylcarbyne- and alkenylvinylidene-tungsten complexes |
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| Synthesis of 9-deoxo-9a-aza-9a-homoerythromycin A 11,12-hydrogen borate and azithromycin 11,12-hydrogen borate. A new procedure to obtain azithromycin dihydrate |
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| Alkenyl Fischer carbene complexes and alpha,beta-unsaturated imine derivatives: Synthesis of azepines and mechanistic NMR studies |
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| Synthesis and characterization of tungsten alkenyl-carbyne and alkenyl-ketenyl complexes containing dithio ligands. X-ray crystal structure and MO analyses of [(dppe){kappa(3)(S,C,S)-S2CPCy3}W CCH=C(CH2)(3)CH2][BF4] |
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