| Third Report on Chicken Genes and Chromosomes 2015: |
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| Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103 |
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| Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin ? |
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| Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation |
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| DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis |
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| Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice |
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| High-Affinity IgG Antibodies Develop Naturally in Ig-Knockout Rats Carrying Germline Human IgH/Ig kappa/Ig lambda Loci Bearing the Rat C-H Region |
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| The cytoplasmic AID complex |
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| Wartime discoveries on amino acids: Functions in protein structure and as a dietary nitrogen source |
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| Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung(-/-)Msh2(-/-) mice |
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| Mutational processes molding the genomes of 21 breast cancers |
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| CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31 |
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| The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification |
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| The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin |
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| Reg-? associates with and modulates the abundance of nuclear activation-induced deaminase |
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| Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1? (eEF1A) |
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| Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci |
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| Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy |
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| Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID |
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| AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity |
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| The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence |
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| The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3 |
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| Interaction between Antibody-Diversification Enzyme AID and Spliceosome-Associated Factor CTNNBL1 |
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| Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants |
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| Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1 |
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| Antibody diversification by somatic mutation: From Burnet onwards |
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| Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo |
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| DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives |
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| Dependence of antibody gene diversification on uracil excision |
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| Molecular mechanisms of antibody somatic hypermutation |
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| Somatic hypermutation: Activation-induced deaminase for C/G followed by polymerase ? for A/T |
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| The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2(-/-) ung(-/-) mice |
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| MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells |
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| SMUG1 is able to excise uracil from immunoglobulin genes: Insight into mutation versus repair |
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| Mice deficient in APOBEC2 and APOBEC3 |
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| Somatic hypermutation at A•T pairs: Polymerase error versus dUTP incorporation |
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| Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases |
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| Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities |
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| Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in Vivo |
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| Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination |
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| Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation |
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| Preface |
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| By-products of immunoglobulin somatic hypermutation |
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| DNA deamination: Not just a trigger for antibody diversification but also a mechanism for defense against retroviruses |
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| DNA deamination mediates innate immunity to retroviral infection |
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| Immunity through DNA deamination |
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| In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1) |
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| The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G |
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| Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase |
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| Production of antigen-specific human monoclonal antibodies: Comparison of mice carrying IgH/? or IgH/?/? transloci |
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| AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification |
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| Interaction of CD22 with alpha2,6-linked sialoglycoconjugates: Innate recognition of self to dampen B cell autoreactivity? |
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| AID is essential for immunoglobulin V gene conversion in a cultured B cell line |
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| RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators |
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| Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice |
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| Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines |
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| Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation [4] |
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| B cells acquire antigen from target cells after synapse formation |
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| Somatic hypermutation of immunoglobulin ? transgenes: Association of mutability with demethylation |
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| Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination |
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| Epstein-barr virus and the somatic hypermutation of immunoglobulin genes in burkitt's lymphoma cells |
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| Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice |
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| The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line |
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| Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies |
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| Memory in the B-cell compartment: Antibody affinity maturation |
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| B cells extract and present immobilized antigen: Implications for affinity discrimination |
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| Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity |
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| Disruption of mouse polymerase ? (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro |
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| Diversification and selection mechanisms for the production of protein repertoires: Lessons from the immune system |
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| The contribution of somatic hypermutation to the diversity of serum immunoglobulin: Dramatic increase with age |
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| Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation |
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| Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies |
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| Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and ? and ? light chain yeast artificial chromosomes |
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| Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response |
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| Both DNA strands of antibody genes are hypermutation targets |
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| Mice carrying a CD20 gene disruption |
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| Monitoring and interpreting the intrinsic features of somatic hypermutation |
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| Comparison of the performance of a plasmid-based human Ig? minilocus and Yac-based human Ig? transloci for the production of human antibody repertoires in transgenic mice |
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| Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate |
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| Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting |
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| Multiple sequences from downstream of the J(?) cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain |
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| TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line |
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| Antigen receptor signaling gives lymphocytes a long life |
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| Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene targeted mice |
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| Cells strongly expressing Ig kappa transgenes show clonal recruitment of hypermutation: A role for both MAR and the enhancers |
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| Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: Importance depends on the nature of the antigen-antibody interaction |
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| The immunoglobulin (Ig)? and Ig? cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice |
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| Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones |
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| Somatic hypermutation of immunoglobulin genes |
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| Hyperresponsive B cells in CD22-deficient mice |
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| The Ig? 3'-enhancer triggers gene expression in early B lymphocytes but its activity is enhanced on B cell activation |
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| Strategies for expressing human antibody repertoires in transgenic mice |
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| Maturation of the immune response |
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| The targeting of somatic hypermutation |
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| Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D) |
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| Generating high-avidity human mabs in mice |
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| Codon bias targets mutation |
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| Targeting of non-lg sequences in place of the V segment by somatic hyper mutation |
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| Somatic hypermutation |
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| REGULATED ACTIVITY OF THE IGH INTRON ENHANCER (E(MU)) IN THE T-LYMPHOCYTE LINEAGE |
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| Antibodies generated from human immunoglobulin miniloci in transgenic mice |
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| Elements regulating somatic hypermutation of an immunoglobulin ? gene: Critical role for the intron enhancer/matrix attachment region |
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| Somatic mutation of immunoglobulin ? chains: A segment of the major intron hypermutates as much as the complementarity-determining regions |
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| The ?/? sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine- kinase recruitment |
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| The diversity of antigen?specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci |
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| Antigen presentation by the B cell antigen receptor is driven by the ? ? sheath and occurs independently of its cytoplasmic tyrosines |
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| Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots |
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| Membrane immunoglobulin without sheath or anchor |
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| Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes |
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| Association of CD22 with the B cell antigen receptor |
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| Creation of Mice Expressing Human Antibody Light Chains by Introduction of a Yeast Artificial Chromosome Containing the Core Region of the Human Immunoglobulin K Locus |
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| The antigen receptor on B lymphocytes |
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| The Mouse B?Cell Antigen Receptor: Definition and Assembly of the Core Receptor of the Five Immunoglobulin Isotypes |
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| Somatic hypermutation of immunoglobulin ? may depend on sequences 3' of C(?) and occurs on passenger transgenes |
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| Generation of antibody repertoires in transgenic mice |
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| The mouse IgH 3??enhancer |
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| The B-cell antigen receptor of the five immunoglobulin classes |
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| Lymphoid-specific transcriptional activation by components of the IgH enhancer: Studies on the E2/E3 and octanucleotide elements |
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| Developmental regulation of IgM secretion: The role of the carboxy-terminal cysteine |
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| The sequence of the µ transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface |
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| Expression and targeting of intracellular antibodies in mammalian cells |
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| Construction, function and immunogenicity of recombinant monoclonal antibodies |
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| The importance of the 3?-enhancer region in immunoglobulin x gene expression |
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| A second B cell-specific enhancer 3? of the immunoglobulin heavy-chain locus |
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| Lack of somatic mutation in a ? light chain transgene |
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| The immunogenicity of chimeric antibodies |
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| Cellular selection leads to age-dependent and reversible down-regulation of transgenic immunoglobulin light chain genes |
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| Isotype exclusion and transgene down-regulation in immunoglobulin-? transgenic mice |
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| THE IMMUNOGLOBULIN KAPPA-LOCUS CONTAINS A SECOND, STRONGER B-CELL-SPECIFIC ENHANCER WHICH IS LOCATED DOWNSTREAM OF THE CONSTANT REGION |
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| A repertoire of monoclonal antibodies with human heavy chains from transgenic mice |
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| The intron requirement for immunoglobulin gene expression is dependent upon the promoter |
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| Novel antibodies by DNA manipulation |
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| The expression of immunoglobulin genes |
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| The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes. |
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| Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies |
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| Preface |
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| Immunoglobulin gene expression |
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| Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain. |
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| Provision of the immunoglobulin heavy chain enhancer downstream of a test gene is sufficient to confer lymphoid?specific expression in transgenic mice |
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| Regulation of membrane IgM expression in secretory B cells: translational and post-translational events. |
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| Replacing the complementarity-determining regions in a human antibody with those from a mouse |
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| Production of antibody-tagged enzymes by myeloma cells: Application to DNA polymerase I Klenow fragment |
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| Chromosome translocation activates heterogeneously initiated, bipolar transcription of a mouse c-myc gene. |
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| A hapten-specific chimaeric IgE antibody with human physiological effector function |
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| Making novel antibodies by expressing transfected immunoglobulin genes |
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| Transcription cell type specificity is conferred by an immunoglobulin V(H) gene promoter that includes a functional consensus sequence |
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| Recombinant antibodies possessing novel effector functions |
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| Reciprocal chromosome translocation between c-Myc and immunoglobulin ?2b genes |
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| Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. |
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| Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line |
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| Activation of mouse complement by monoclonal mouse antibodies |
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